Break It Up may refer to:
"Break It Up", a song from the 1975 album Horses by Patti Smith "Break It Up" (Foreigner song), 1982 "Break It Up" (Rocket from the Crypt song), 1998 "Break It Up" (Scooter song), 1996 Break It Up (SSD album), 1985 Break It Up (Jemina Pearl album), 2009 "Break It Up", a 1991 song by Cypress Hill from the album Cypress Hill
See also "Break It up, Break It Up", the third episode of The Drew Carey Shows second season